The burden of Huntington's disease: A prospective longitudinal study of patient/caregiver pairs

•Caregiver burden over time in Huntington disease must be considered to improve care.•Determinants of the evolution of caregiver burden are not limited to the stage of patients' disease.•Patients' stage, psychiatric disorders, and disease's dynamics condition burden.•Irritability, obsessions, and depression are major factors in caregiver burden.•Entry into the disease causes burden increase for caregivers.