An ACE2-IgG4 Fc Fusion Protein Demonstrates Strong Binding to All Tested SARS-CoV-2 Variants and Reduced Lung Inflammation in Animal Models of SARS-CoV-2 and Influenza.

Emmanuel Y Merigeon,Dong Yang, Elizabeth A Ihms,Leda C Bassit,Elizabeth A Fitzpatrick,Colleen B Jonsson,Raymond F Schinazi,David S Block,Henrik S Olsen

Pathogens & immunity（2022）

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摘要

G921 data are consistent with both antiviral and anti-inflammatory modes of action. G921 is a novel approach for the prevention and treatment of COVID-19 and possible other diseases characterized by deficiency of ACE2.

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关键词

ACE2,COVID-19,SARS-CoV-2 antiviral agents,anti-inflammatory

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