Elevated β-secretase 1 expression mediates CD4+ T cell dysfunction via PGE2 signalling in Alzheimer’s disease

Linbin Dai,Qiong Wang,Xinyi Lv,Feng Gao,Zuolong Chen,Yong Shen

Brain, Behavior, and Immunity（2021）

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摘要

•BACE1 expression is elevated in CD4+ T cells from AD patients and 5xFAD mice.•BACE1 regulates the activation of CD4+ T cells and promotes immune response.•BACE1 regulates TCR signalling by promoting mPGES2 maturation and PGE2 production.•Peripheral PGE2 signalling antagonists ameliorates the Aβ pathology in 5xFAD mice.

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关键词

β-secretase,CD4+ T cell,PGE2 signalling,Alzheimer’s disease,Neuroinflammation,T cell receptor (TCR)

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