Baicalein ameliorates ischemic brain damage through suppressing proinflammatory microglia polarization via inhibiting the TLR4/NF-κB and STAT1 pathway

Yuanyuan Ran,Shuyan Qie,Fuhai Gao,Zitong Ding,Shuiqing Yang,Guiqin Tian,Zongjian Liu,Jianing Xi

Brain Research（2021）

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摘要

•Baicalein improves infarct volume and sensorimotor functions after MCAO.•Baicalein modulates microglial polarization to anti-inflammatory phenotype.•Baicalein regulates the neuroinflammatory response.•Baicalein affects polarization via inhibiting the TLR4/NF-κB and STAT1 activity.•Baicalein inhibits the toxicity of proinflammatory microglia on post-OGD neurons.

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关键词

Baicalein,Neuroinflammation,Microglial polarization,NF-κB,STAT1

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