Joint Modeling Study Identifies Blood‐Based Transcripts Link to Cognitive Decline in Parkinson's Disease

Junfeng Luo,Hao Wu, Jinxia Li,Wenbiao Xian,Weimin Li,Joseph J. Locascio,Zhong Pei,Ganqiang Liu

Movement Disorders（2022）

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摘要

Our transcriptome-wide joint modeling analysis uncovered five blood-based transcripts related to cognitive decline in PD. The joint models will serve as a useful resource for clinicians and researchers to screen PD patients with high risk of development of cognitive impairment and pave the path for Parkinson's personalized medicine. © 2022 International Parkinson and Movement Disorder Society.

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关键词

Parkinson's disease,cognitive decline,joint model,longitudinal transcripts,personalized medicine

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