Brain Concentrations of MDPV and its Metabolites in Male Rats: Relationship to Pharmacodynamic Effects.

Marta Concheiro, Steven Towler,Joshua S Elmore,Michael R Chojnacki,Teeshavi Acosta,Masaki Suzuki,Kenner C Rice,Michael H Baumann

Current pharmaceutical design（2022）

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摘要

The behavioural effects of MDPV are related to brain concentrations of the parent drug and not its metabolites. The modest effects of MDPV on monoamine systems suggest that other non-monoamine mechanisms may contribute to the effects of the drug in vivo.

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关键词

MDPV,brain,pharmacodynamics,pharmacokinetics,plasma,synthetic cathinones

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