NLRP3 leucine-rich repeats control induced and spontaneous inflammasome activation in cryopyrin-associated periodic syndrome

Katerina Theodoropoulou,Lotte Spel,Léa Zaffalon,Maeva Delacrétaz,Michaël Hofer,Fabio Martinon

Journal of Allergy and Clinical Immunology（2023）

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摘要

These findings demonstrate the contribution of the LRR domain in inflammasome function and suggest that navigating LRR exon usage within NLRP3 is sufficient to dampen inflammasome assembly in CAPS.

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关键词

Inflammasome,NLRP3,LRR,cryopyrin,autoinflammatory disease,CAPS,cryopyrinopathies,alternative splicing

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