Clinicogenomic associations in childhood Langerhans cell histiocytosis: an international cohort study

Paul G. Kemps,Timo C. E. Zondag, Helga B. Arnardóttir,Nienke Solleveld-Westerink,Jelske Borst,Eline C. Steenwijk,Demi van Egmond,Joost F. Swennenhuis,Ellen Stelloo,Irene Trambusti,Robert M. Verdijk,Carel J. M. van Noesel,Arjen H. G. Cleven,Marijn A. Scheijde-Vermeulen,Marco J. Koudijs,Lenka Krsková,Cynthia Hawkins,R. Maarten Egeler,Jesper Brok,Tatiana von Bahr Greenwood

Blood advances（2023）

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摘要

•Oncogenic mutation subtype appears an important driver of heterogeneity in clinical presentation of pediatric LCH.•Lesional BRAFV600E status is not a significant prognostic factor for event-free survival independent from disease extent.

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childhood langerhans cell histiocytosis,clinicogenomic associations,cohort study

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