Genome-Scale CRISPR screen identifies LAPTM5 driving lenvatinib resistance in hepatocellular carcinoma.

Jiaomeng Pan,Mao Zhang,Liangqing Dong,Shuyi Ji,Juan Zhang,Shu Zhang,Youpei Lin,Xiaoying Wang,Zhenbin Ding,Shuangjian Qiu,Daming Gao,Jian Zhou,Jia Fan,Qiang Gao

Autophagy（2023）

引用 10|浏览28

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摘要

cld-CASP3: cleaved caspase 3; cld-PARP: cleaved PARP; DTP: drug tolerant persister; GO: Gene Ontology; GTEx: The Genotype-Tissue Expression; HCC: hepatocellular carcinoma; HCQ: hydroxychloroquine; IC50: half maximal inhibitory concentration value; KEGG: Kyoto Encyclopedia of Genes and Genomes; LAPTM5: lysosomal protein transmembrane 5; NT: non-targeting; PDC: patient-derived primary cell lines; PDO: patient-derived primary organoid; TCGA: The Cancer Genome Atlas.

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关键词

Autophagy,LAPTM5,drug resistance,lenvatinib,liver cancer,whole-genome CRISPR-Cas9 screen

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