Activated Pathways of Myastenia Gravis in Thymic Epithelial (TETs)

J. C. Benitez,B. Job,V. Thomas De Montpreville,L. Lacroix, P. Saulnier, R. Arana, O. Lambotte, S. Mussot, O. Mercier, E. Fadel, J. Florez-Arango, J. -Y. Scoazec, T. Molina,B. Besse

Journal of Thoracic Oncology（2022）

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摘要

TETs are rare malignancies of the anterior mediastinum. Clinical behavior varies from mild thymoma (T) A to aggressive thymic carcinoma (TC). Up to 30% of patients will develop associated autoimmune disorders (AIDs), mainly myasthenia gravis (MG). The biology of TETs and its relation with the development of AIDs is poorly understood. We aimed to characterize the main cancer activation pathways of MG in TETs.

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关键词

thymoma, myastenia gravis, molecular characterisation

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