Angiopoietin 2 and hsCRP are associated with pulmonary hemodynamics and long-term mortality respectively in CTEPH-Results from a prospective discovery and validation biomarker study.

Charaka M Hadinnapola,Mark Southwood,Jules Hernández-Sánchez,Katherine Bunclark,Michael Newnham,Emilia M Swietlik,John Cannon,Stephen D Preston,Karen Sheares,Dolores Taboada,Nicholas Screaton,David P Jenkins,Nicholas W Morrell,Mark Toshner,Joanna Pepke-Zaba

The Journal of Heart and Lung Transplantation（2023）

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摘要

We hypothesize that CTEPH patients have significant distal micro-vasculopathy and consequently high circulating Ang2. Patients with CTEPD without pulmonary hypertension have no discernible distal micro-vasculopathy and therefore have low circulating Ang2. This suggests Ang2 may be critical to CTEPH disease pathogenesis (impaired thrombus organization and disease severity).

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关键词

CTEPH,angiogenesis,angiopoietin 2,inflammation

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