Genetic stratification of motor and QoL outcomes in Parkinson's disease in the EARLYSTIM study

Parkinsonism & Related Disorders（2022）

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摘要

•SNCA rs356220 did not predict UPDRS III in STN-DBS group of PD patients.•SNCA rs356220 was associated with quality-of-life improvement.•Different SNPs from PD GWAS hits predicted motor or PDQ-39 outcomes.•Further validation in larger cohorts is needed to confirm these findings

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关键词

Parkinson's disease,Deep brain stimulation,Alpha-synuclein,Genetic association

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