MA01.09 Characterising Aggressive Pulmonary Carcinoids Through Integrative Omics Analysis Within the lungNENomics Project

Typical and atypical carcinoids are well differentiated lung neuroendocrine tumours (LNETs) that belong to the group of lung neuroendocrine neoplasms, which also include highly aggressive lung neuroendocrine carcinomas (LNECs). Although carcinoids show relatively good prognosis in comparison to carcinomas, metastatic disease and relapse do occur. In a previous study we introduced the concept of molecular groups of carcinoids: A (further separated into A1 and A2) and B, which did not clearly correspond to individual histological types. Additionally, we identified six tumours, termed supra-carcinoids, that displayed genuine carcinoid-like morphology, but had clinical and molecular characteristics of LNECs. In comparison to carcinoid A, overall survival rates were lower for the more aggressive carcinoid B and supra-carcinoid tumours. As yet, little is known about the underlying biology or developmental origins of these two groups of aggressive carcinoids, hampering efforts to identify predictive markers and suitable therapeutic options.