A comparative assessment of myelin-sensitive measures in multiple sclerosis patients and healthy subjects

Reza Rahmanzadeh,Matthias Weigel,Po-Jui Lu,Lester Melie-Garcia,Thanh D Nguyen,Alessandro Cagol,Francesco La Rosa,Muhamed Barakovic,Antoine Lutti,Yi Wang,Meritxell Bach Cuadra,Ernst-Wilhelm Radue,Laura Gaetano,Ludwig Kappos,Jens Kuhle,Stefano Magon,Cristina Granziera

NeuroImage: Clinical（2022）

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摘要

•qT1 and QSM showed the highest sensitivity to distinguish MS focal WM and cortical pathology from peri-plaque.•MWF and MTsat exhibited the highest sensitivity to NAWM pathology.•qT1 appeared to be the most sensitive measure to NAGM pathology.•All myelin-sensitive qMRI measures exhibited high intra-scanner reproducibility.

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关键词

Multiple sclerosis,Quantitative MRI,Myelin,Reproducibility,Sensitivity

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