Cisatracurium regulates the CXCR4/let-7a-5p axis to inhibit colorectal cancer progression by suppressing TGF-β/SMAD2/3 signalling

•Cisatracurium suppressed cell viability and metastasis in CRC cell lines.•Cisatracurium repressed CRC through inhibition of TGF-β/SMAD2/3 signalling.•Cisatracurium reduced CXCR4 level by inhibiting of TGF-β/SMAD2/3 signalling.•Cisatracurium enhanced let-7a-5p expression through inhibiting CXCR4.•CXCR4/let-7a-5p axis acted as a target of cisatracurium in CRC progress.