Excessive Gluconeogenesis Causes the Hepatic Insulin Resistance Paradox and Its Sequelae
SSRN Electronic Journal（2022）
摘要
HIR-induced excessive gluconeogenesis is a major cause of the HIR paradox and its sequelae. Such involvement of gluconeogenesis in lipid synthesis rationalizes the fact that several types of antidiabetic drugs ameliorate NAFLD. Thus, dietary, lifestyle and pharmacological targeting of HIR and hepatic gluconeogenesis may be a most viable approach for the prevention and management of the HIR-associated network of diseases.
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关键词
Endoplasmic reticulum stress,Hexosamine biosynthetic pathway,Polyol pathway,Reactive oxygen species,Reductive carboxylation,Reductive stress
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