Tigliane and rhamnofolane glycosides from Euphorbia wallichii prevent oxidative stress-induced neuronal death in PC-12 cells

•Twelve new tigliane/rhamnofolane glycosides were isolated from Euphorbia wallichii.•The aglycones of 1–5 represent a rare class of 13-deoxygenated tiglianes.•The aglycones of 8–12 represent the first examples of 4-deoxygenated rhamnofolanes.•Euphorwallside C (3) was identified as a promising neuroprotective agent.•3 inhibit ROS accumulation and restore the MMP via Nrf2 signaling pathway.