Isoandrographolide from Andrographis paniculata ameliorates tubulointerstitial fibrosis in ureteral obstruction-induced mice, associated with negatively regulating AKT/GSK-3β/β-cat signaling pathway

Zhenzhen Guan,Yaming Wang,Haiwei Xu, Yake Wang,Di Wu,Zhizi Zhang,Zihan Liu,Ning Shang,Di Zhang, Jingyang Sun, Xugang He,Yingxue Li,Lina Zhu,Zhentao Liu,Mingliang Zhang,Zhihao Xu,Zhe Song,Guifu Dai

International Immunopharmacology（2022）

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摘要

•Isoandrographolide exhibited lower toxicity and higher efficiency than AD on HK-2 cells.•Isoandrographolide suppressed the excessive deposition of extracellular matrix and prevented TIF.•Isoandrographolide attenuated EMT and inflammation, and thereby ameliorated TIF in UUO-induced mice.•Isoandrographolide inhibited AKT/GSK-3β/β-catenin signaling.•Isoandrographolide might be a promising lead agent to prevent and treat TIF.

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关键词

Isoandrographolide,Renal fibrosis,Epithelial-mesenchymal transition,Inflammation,Network pharmacology,AKT/GSK-3β/β-catenin signaling

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