RANKL down-regulates the mast cell proliferation through inducing senescence

Jin-Ho Lim,Hee-Yun Kim,Ho-Geun Kang,Hyun-Ja Jeong,Hyung-Min Kim

Cytokine（2022）

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摘要

•RANKL remarkably reduced proliferation of HMC-1 cells.•RANKL increased SA-b-gal activity and p53, p-p53, and p21 expression in TSLP-stimulated HMC-1 cells.•RANKL down-regulates mast cell proliferation through inducing senescence.

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关键词

RANKL,Proliferation,Mast cell,TSLP,Senescence

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