Household profiles of neglected tropical disease symptoms among children: A latent class analysis of built-environment features of Tanzanian households using the Demographic and Health Survey

Background While malaria and neglected tropical disease (NTD) mor-bidity and mortality rates among children <5 years old have decreased through public health efforts in the United Republic of Tanzania, associ-ations between household environments and disease outcomes are rela-tively unknown.Methods We conducted latent class analysis (LCA) on 2015-2016 Tanza-nia Demographic Health Survey data from mothers with children <5 years old (N = 10 233) to identify NTD household risk profiles. The outcome of child NTD was assessed by mothers' reports of recent diarrhoea, cough, treatment for enteric parasites, and fever symptoms. Household-built en-vironment indicators included urban/rural designation, electricity access, water source, cooking fuel, flooring, wall, and roofing materials. External environmental covariates were considered to further differentiate profiles.Results Five profiles were identified in the sample: rural finished walls households (40.2%) with the lowest NTD risk; rural rudimentary house-holds (20.9%) with intermediate-low NTD risk; finished material house-holds (22.5%) with intermediate NTD risk; urban households (14.4%) with intermediate-high NTD risk and high likelihood of enteric para-sites; rural finished roof/walls households (2.1%) with the highest over-all NTD risk.Conclusions This study is among the first to use LCA to examine house-hold environment characteristics to assess child NTD risk in Tanzania. This paper serves as a framework for community-level rapid NTD risk as-sessment for targeted health promotion interventions.