Mechanistic Target of Rapamycin Inhibition Prevents Coronary Artery Remodeling in a Murine Model of Kawasaki Disease.

Angus T Stock,Sarah Parsons,Damian B D'Silva,Jacinta A Hansen,Varun J Sharma,Fiona James,Graham Starkey,Rohit D'Costa,Claire L Gordon,Ian P Wicks

Arthritis & rheumatology (Hoboken, N.J.)（2023）

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摘要

Our findings demonstrate that mTOR signaling contributes to coronary artery remodeling in KD, and that targeting this pathway offers a potential therapeutic strategy to prevent or restrict this pathology in high-risk KD patients.

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kawasaki disease

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