A Series of Trifluoromethylisoxazolyl- and Trifluoromethylpyrazolyl- Substituted (Hetero)aromatic Sulfonamide Carbonic Anhydrase Inhibitors: Synthesis, and Convenient Prioritization Workflow for Further In Vivo Studies.
Medicinal chemistry (Shariqah (United Arab Emirates))（2023）
摘要
Coupling the bCA esterase activity assay with thermal shift assay represents a streamlined and economical strategy for the prioritization of sulfonamide CA inhibitors for subsequent evaluation in vivo.
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关键词
Carbonic anhydrase,bicarbonate,carbon dioxide,sulfonamides,trifluoromethyl group,zinc-binding groups
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