Microwave‐Assisted Reductive Amination of 2‐Carboxybenzaldehydes with Amines for the Synthesis of N‐Substituted Isoindolin‐1‐one

ChemistrySelect(2022)

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摘要
Microwave-assisted, transition metal free methodology for the synthesis of N-substituted isoindolin-1-one from 2-carboxybenzaldehydes with various amines by reductive amination reaction using formic acid has been described. This method is relatively simple, benign and safe which tolerates a variety of functional groups.
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关键词
2-Carboxy benzaldehyde, Formic acid, Imine, isoindolinone, Microwave
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