Small-molecule High-throughput Screening Identifies an MEK Inhibitor PD198306 that Enhances Sorafenib Efficacy via MCL-1 and BIM in Hepatocellular Carcinoma Cells.
Combinatorial chemistry & high throughput screening（2023）
摘要
Small-molecule qHTS identifies MEK inhibitor PD1938306 as a potent sorafenib enhancer, together with several novel combination strategies that are valuable for further studies.
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关键词
MEK inhibitor,Small-molecule high-throughput screening,angiogenesis,calcium channel blocker,hepatocellular carcinoma,sorafenib
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