Activation of the pattern recognition receptor NOD1 in periodontitis impairs the osteogenic capacity of human periodontal ligament stem cells via p38/MAPK signalling.

Yuying He,Zuping Wu,Sirui Chen,Jiahe Wang,Li Zhu,Jing Xie,Chenchen Zhou,Shujuan Zou

Cell proliferation（2022）

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摘要

Our study revealed the expression status of NOD1 in periodontitis. Its activation greatly decreased the osteogenic capacity of hPDLSCs which was mediated by the phosphorylation of p38 downstream signalling.

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