Novel transketolase inhibitor oroxylin A suppresses the non‐oxidative pentose phosphate pathway and hepatocellular carcinoma tumour growth in mice and patient‐derived organoids

Dan Jia,Chunliang Liu,Zhenyu Zhu,Yan Cao,Wen Wen,Zhanying Hong,Yue Liu, Erdong Liu,Long Chen,Chun Chen,Yanqiu Gu,Binghua Jiao,Yifeng Chai,Hong‐yang Wang,Jing Fu,Xiaofei Chen

Clinical and Translational Medicine（2022）

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摘要

These results uncover a unique role for oroxylin A in TKT inhibition, which directly targets TKT and suppresses the non-oxidative PPP. Our findings will facilitate the development of small-molecule inhibitors of TKT and novel therapeutics for HCC.

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关键词

metabolic reprogramming,non-oxidative pentose phosphate pathway,oroxylin A,patient-derived organoids,transketolase

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