Genetic disruption of the Gipr in Apoe -/- mice promotes atherosclerosis.

Gemma Pujadas,Laurie L Baggio,Kiran Deep Kaur,Brent A McLean,Xiemin Cao,Daniel J Drucker

Molecular metabolism（2022）

引用 5|浏览10

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摘要

Loss of the Gipr in mice results in increased aortic atherosclerosis and enhanced inflammation in aorta and liver, despite reduced weight gain and preserved glucose homeostasis. These findings extend concepts of GIPR in the suppression of inflammation-related pathophysiology beyond its classical incretin role in the control of metabolism.

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关键词

Glucose-dependant insulinotropic polypeptide receptor,atherosclerosis,blood vessel,cholesterol,incretin,inflammation

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