Role of histone deacetylase 3 in immunophenotype of adipose tissue

Background and Aims : Obesity is associated to comorbidities like cardiovascular disease, type 2 diabetes, and infectious diseases. We showed that histone deacetylase 3 (HDAC3) regulates white adipose tissue (WAT) physiology and its genetic inactivation leads to metabolic rewiring of WAT towards browning. Since inflammation of WAT affects adipocyte functionality, we aimed to explore the immunophenotype of WAT from Hdac3 KO (H3fatKO) mice to test whether the observed phenotype was associated to different immune cell profile.