Bioactive lipids and lipoprotein lipase in epicardial adipose tissue from patients with coronary artery disease: Unfolding a missing link

Background and Aims : Epicardial adipose tissue (EAT) contributes to atherosclerotic cardiovascular disease (ASCVD). EAT presents a specific lipidomic signature, with increased proinflammatory lipids, such as ceramides (Cer). Besides the activity of lipoprotein lipase (LPL) in EAT, supplying fatty acids to the tissue, would contribute to its expansion. Our aim was to evaluate links among LPL activity and bioactive lipids in EAT from coronary disease (CAD) patients.