Modulation of POPDC1 Expression by Phenothiazine and Trifluoperazine Suppress Colon Cancer Growth and Migration.

Fiona Macniesia Thomas,Suhaini Sudi,Falah Abas Muhamad Salih, Praneetha Palasuberniam,Latifah Suali, Mohd Hijaz Mohd Sani,Caroline Sunggip

Asian Pacific journal of cancer prevention : APJCP（2022）

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摘要

These findings suggest that CaM antagonists suppress colon cancer cells proliferation via downregulation of CD1 and PCNA. In addition, POPDC protein could be used as a biomarker in colon cancer, and CaM antagonist could be used to regulate POPDC1 expression. This study suggests that targeting POPDC1 with CaM inhibition could be a potential therapeutic strategy for colon cancer treatment.
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关键词

Colon cancer,POPDC,calmodulin antagonist

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