[Effect of moxibustion on autophagy lysosome function mediated by mTOR/TFEB pathway and lncRNA H19 expression in APP/PS1 double transgenic mice].

Yu-Mei Jia,Cai-Feng Zhu,Kun Yang,Cheng-Gong He,Yang-Yang Wu,Ling Wang,Ren-Fei Song,Jia-Yu Zhang,Chi Wang

Zhen ci yan jiu = Acupuncture research（2022）

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摘要

Moxi at acupoints of Governor Vessel can improve cognitive function of AD mice, which may be associated with its functions in inhibiting mTOR/TFEB pathway by down-regulating the expression of lncRNA H19, improving autophagy lysosomal function, promoting autophagy and clearing away Aβ1-42 in the hippocampus.

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关键词

Alzheimer’s disease,Autophagy,Hippocampus,Learning-memory ability,Long noncoding RNA H19,Moxibustion,mTOR/TFEB pathway

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