Brain Structure in Acutely Underweight and Partially Weight-Restored Individuals With Anorexia Nervosa: A Coordinated Analysis by the ENIGMA Eating Disorders Working Group.

Esther Walton,Fabio Bernardoni,Victoria-Luise Batury,Klaas Bahnsen,Sara Larivière,Giovanni Abbate-Daga,Susana Andres-Perpiña,Lasse Bang,Amanda Bischoff-Grethe,Samantha J Brooks,Iain C Campbell,Giammarco Cascino,Josefina Castro-Fornieles,Enrico Collantoni,Federico D'Agata,Brigitte Dahmen,Unna N Danner,Angela Favaro,Jamie D Feusner,Guido K W Frank,Hans-Christoph Friederich,John L Graner,Beate Herpertz-Dahlmann,Andreas Hess,Stefanie Horndasch,Allan S Kaplan,Lisa-Katrin Kaufmann,Walter H Kaye,Sahib S Khalsa,Kevin S LaBar,Luca Lavagnino,Luisa Lazaro,Renzo Manara,Amy E Miles,Gabriella F Milos,Alessio Maria Monteleone,Palmiero Monteleone,Benson Mwangi,Owen O'Daly,Jose Pariente, Julie Roesch,Ulrike H Schmidt,Jochen Seitz,Megan E Shott,Joe J Simon,Paul A M Smeets,Christian K Tamnes,Elena Tenconi,Sophia I Thomopoulos,Annemarie A van Elburg,Aristotle N Voineskos,Georg G von Polier,Christina E Wierenga,Nancy L Zucker,Neda Jahanshad,Joseph A King,Paul M Thompson,Laura A Berner,Stefan Ehrlich

Biological psychiatry（2022）

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摘要

The effect sizes observed for cortical thickness deficits in acute AN are the largest of any psychiatric disorder investigated in the ENIGMA (Enhancing Neuro Imaging Genetics through Meta Analysis) Consortium to date. These results confirm the importance of considering weight loss and renutrition in biomedical research on AN and underscore the importance of treatment engagement to prevent potentially long-lasting structural brain changes in this population.

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关键词

BMI,Cortical thickness,MRI,Subcortical volume,Surface area

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