Distinct brain iron profiles associated with logopenic progressive aphasia and posterior cortical atrophy

Neha Atulkumar Singh,Arvin Arani,Jonathan Graff-Radford,Matthew L Senjem,Peter R Martin,Mary M Machulda,Christopher G Schwarz,Yunhong Shu,Petrice M Cogswell,David S Knopman,Ronald C Petersen,Val J Lowe,Clifford R Jack,Keith A Josephs,Jennifer L Whitwell

NeuroImage: Clinical（2022）

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摘要

•QSM is an informative candidate marker for studying brain iron distribution patterns.•Iron deposition could potentially differ between logopenic progressive aphasia and posterior cortical atrophy.•QSM could potentially differentiate between the atypical and typical variants of AD.

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关键词

QSM,tAD,LPA,PCA,Pb,AD,Aβ,MoCA,BNT,BDAE,AVLT-RCP,Rey-O,VOSP,MPRAGE,3D-MEGRE,MCALT,ROI,SUVRs

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