When Things Go Awry in Axons

Fabrizio Passalacqua, Kyle Leatt, Nikita Chawla, Ruth-Ann Saddler,Elisabetta Babetto,Bogdan Beirowski

Frontiers for Young Minds(2022)

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摘要
Axons are the thin and long extensions of neuronal cells that snake away from the cell body. Axons in our nervous system are like bridges spanning long distances to bring information from one nerve cell to another. However, axons are alive and need nutrients and energy to survive. Axons degenerate if nutrients and energy run out. This results in devastating symptoms in many conditions called neurodegenerative diseases. Scientists must understand why and how axons degenerate to prevent or delay it from happening. Recent studies have identified a destruction process that leads to energy loss and death of injured axons. The destruction pathway is completed by a rogue “demolition crew” driven by the watchdog molecule SARM1. Blocking this demolition crew delays the death of injured axons and helps sick axons. These findings may lead to new therapies that can decrease the symptoms of many people suffering from neurodegenerative diseases.
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关键词
axons,things
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