Time to culture conversion of bedaquiline and high-dose isoniazid for drug resistant tuberculosis

Kathleen F Walsh,Stalz Charles Vilbrun,Ariadne Souroutzidis,Joshua Ellis, Sobiesyke Delva,Guy Joissaint,Kathryn M Dupnik,Patrice Joseph,Jean W Pape,Serena P Koenig

Open Forum Infectious Diseases（2022）

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摘要

Abstract Patients with multidrug-resistant tuberculosis (MDR-TB) who received regimens containing high dose isoniazid (INHHD) had similar time to culture conversion and treatment outcomes as patients who received regimens with bedaquiline (BDQ). INHHD is an inexpensive and safe medication which may contribute additive efficacy in combination regimens.

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关键词

bedaquiline, drug-resistant tuberculosis, high-dose isoniazid, time to culture conversion, treatment outcomes

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