A Second-generation opioid LC-MS/MS assay improves laboratory workflow and capacity

Hsuan-Chieh Liao,Thomas J. Laha,Geoffrey S. Baird,Ka Keung Chan,Andrew N. Hoofnagle

Journal of Chromatography B（2022）

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摘要

•Improved chromatography eliminated isobaric interferences.•Upgraded mass spectrometers provided better sensitivity and specificity and greater dynamic ranges.•Developed and validated a simplified “dilute-and-shoot" LC-MS/MS opioid assay.•The new opioid assay reduced turnaround time and doubled testing capacity.

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关键词

LC-MS/MS,Opioid,Dilute-and-shoot,Workflow and capacity

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