Impact of a cell cycle and an extracellular matrix remodeling transcriptional signature on tumor progression and correlation with EZH2 expression in meningioma.

Benedito Jamilson Araújo Pereira,Antonio Marcondes Lerario,Paula Rodrigues Sola,Talita de Sousa Laurentino,Dipika R Mohan,Antonio Nogueira de Almeida,Paulo Henrique Pires de Aguiar,Wellingson da Silva Paiva,Alda Wakamatsu,Manoel Jacobsen Teixeira,Sueli Mieko Oba-Shinjo,Suely Kazue Nagahashi Marie

Journal of neurosurgery（2023）

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摘要

The authors identified modules of dysregulated genes in grade 2 meningiomas related to the activation of oxidative metabolism, cell division, cell motility due to extracellular remodeling, and immune evasion that were predictive of survival and exhibited significant correlations with EZH2 expression.

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关键词

meningioma recurrence,somatic mutations,transcriptomic profile,tumor

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