HIGH MOBILITY GROUP BOX-1 IS INCREASED IN NEWLY DIAGNOSED ESSENTIAL HYPERTENSIVES AND CORRELATES WITH HYPERTENSION-MEDIATED TARGET ORGAN DAMAGE.

Antonios Lazaridis,Eleni Gavriilaki,Panagiotis Dolgyras,Nikolaos Koletsos,Areti Triantafyllou,Panagiota Anyfanti, Olga Pavlidou,Kyriakos Goulas,Stella Douma,Eugenia Gkaliagkousi

Journal of hypertension（2022）

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摘要

HMGB1 is significantly increased in UHTs compared to NTs and correlates with indices of macro- and microvascular damage. These results reinforce the concept that immune system activation contributes to hypertension-mediated TOD from the very early stages and point towards intense research in order to investigate novel potential therapeutic targets related to EH.

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关键词

essential hypertensives,hypertension-mediated

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