BI 2536 induces gasdermin E-dependent pyroptosis in ovarian cancer.

In this study, we identified BI 2536 as an effective anti-ovarian cancer drug that inhibits proliferation, arrests the cell cycle, induces apoptosis and pyroptosis, and leads to the accumulation of CD8 T cells in tumor sites. Drug-induced pyroptosis may have promising prospects for reducing side effects and activating immune responses.