Urinary phthalate metabolites and their mixtures are associated with advanced sperm epigenetic aging in a general population

Oladele A Oluwayiose,Emily Houle,Haotian Wu,Brian W Whitcomb,Sunni L Mumford,Enrique F Schisterman,Alexander Suvorov,Laura B Balzer,J Richard Pilsner

Environmental Research（2022）

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摘要

•Urinary metabolite concentrations of MEHHP, MiBP, and MMP were positively associated with sperm epigenetic aging (SEA).•There was an overall positive trend between phthalate metabolite mixtures and SEA, with MiBP, MMP and MBzP as major drivers.•Our results suggest that phthalate exposures in adult males contribute to the acceleration of biological aging of sperm.

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关键词

Sperm epigenetic clock,Phthalate metabolites,Aging,DNA methylation,Mixtures

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