Chorea as a post‐COVID‐19 complication.

Severe acute respiratory syndrome (SARS) coronavirus (COV)-2 causes flu-like symptoms, including fever, cough, fatigue, and loss of sense of smell. Although many complications of this unprecedented virus have been specified, there is still a lack of information on neurologic post-recovery complications. Studies suggest that this rapidly spreading virus can invade the nervous system and cause neurological problems even after recovery.1 The most common neurological complications include headache, dizziness, myalgia, anosmia, gustatory, and olfactory dysfunctions.2 Severe disorders such as encephalopathy, encephalitis, necrotizing hemorrhagic encephalopathy, stroke, epileptic seizures, rhabdomyolysis, and Guillain-Barre syndrome have also been reported after coronavirus disease (COVID)-19 infection.3 There are just six case reports on post-COVID-19 chorea. As far as we know, the two patient cases noted below are the first to be reported with more than a 2-week interval between post-COVID-19 encephalitis and initiation of chorea.4-11 A 67-year-old woman was referred to the movement disorder clinic because of acute onset of generalized choreiform movements. She stated an earlier admission because of coronavirus symptoms including nausea, loss of appetite, and high blood pressure 3 months prior. Moreover, she tested positive for coronavirus reverse-transcription polymerase chain reaction (RT-PCR) by nasopharyngeal swab. Additionally, 2 weeks after the beginning of her COVID-19 infection, she developed confusion, illusion, aphasia, imbalance, and delirium. Consequently, she was diagnosed with post-COVID-encephalitis and received a tocilizumab injection. She was vaccinateded for COVID-19 (AstraZeneca) 4 months previously. Her family history and previous history of any abnormal movements in any part of her body were negative. She had normal neurological and systemic examinations. However, she was suffering from choreiform movements in her face and all four limbs, with right arm dominancy (Video 1). Brain magnetic resonance imaging (MRI) showed bilateral hyperintensity on fluid-attenuated inversion recovery and T2 imaging on basal ganglia (Fig. 1). She was treated with tetrabenazine (12.5 mg twice daily). After a few days, her symptoms recovered rapidly, and she was discharged. Another 62-year-old otherwise healthy female presented to the movement disorder clinic because she experienced sudden onset abnormal movements in her truncal and limbs. She had been admitted 15 days previously because of her COVID-19 infection and treated with a remdesivir injection. Her past medical history, drug history, and family history were unremarkable. She had no pathological findings in examinations and brain MRI. Nonetheless, she had choreiform movements on her extremities, especially on the right side (Video 2). She was treated with tetrabenazine and chorea dramatically mended. In both cases, laboratory tests including complete blood count, basic metabolite assessment (sodium, potassium, calcium, chloride, carbon dioxide, albumin, blood urea nitrogen, and fasting blood sugar), lipid panel, liver-thyroid function tests, and paraneoplastic panels were found to be at normal ranges. However, there was an increase in erythrocyte sedimentation rate and C-reactive protein levels in case 2. Accordingly, chorea was considered to be a complication of COVID-19 infection. Societies have been greatly affected by COVID-19 consequences. These complications need to be elucidated. As mentioned earlier, neurologic complications after COVID-19 infection have been stated before. Here, we report two women with right dominant choreiform movements that, unlike other reports, showed chorea after 2 weeks from COVID-19 infection. Literature that includes choreiform movements after coronavirus infection, published up to March 2022, was reviewed (Table 1). Subsequently, the relevant six case reports were extracted. We included our case report on hemichorea after the BBIBP-CorV (Sinopharm) vaccine.12 Although this is a rare condition, clinicians must be conscious of this possible outcome. (1) Research project: A. Conception, B. Organization, C. Execution. 2 Manuscript: A. Writing of the First Draft, B. Review and Critique. F.A.: 1A, 1B, 1C. M.S.:1A, 1B, 1C, 2A. F.H.P.: 2A. Ethical Compliance Statement: This study was reviewed by Shahid Beheshti University of medical sciences. The patients have given written and informed consent for online publication of their videos. We confirm that we have read the Journal's position on issues involved in ethical publication and affirm that this work is consistent with those guidelines. Funding Sources and Conflicts of Interest: The authors declare that there are no conflicts of interest relevant to this work. Financial Disclosures for the Previous 12 Months: The authors declare that there are no additional disclosures to report.