The unique effect of TDP-43 on hippocampal subfield morphometry and cognition.

Ashley Heywood,Jane Stocks,Julie A Schneider,Konstantinos Arfanakis,David A Bennett,Mirza Faisal Beg,Lei Wang

NeuroImage. Clinical（2022）

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摘要

•We explored postmortem TDP-43 burden and antemortem hippocampal surface deformation.•TDP-43 was uniquely associated with inward deformation in the hippocampus.•Deformation patterns account for co-existing disease showing TDP-43′s unique effect.•Deformation was significantly correlated with cognition scores.

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