Citrullination is linked to reduced Ca 2+ sensitivity in hearts of a murine model of rheumatoid arthritis.

Gianluigi Pironti,Stefano Gastaldello,Dilson E Rassier,Johanna T Lanner,Mattias Carlström,Lars H Lund,Håkan Westerblad,Takashi Yamada,Daniel C Andersson

Acta physiologica (Oxford, England)（2022）

引用 3|浏览2

暂无评分

摘要

Using a mouse RA model we found evidence of impaired cardiac contractile function linked to reduced Ca sensitivity, increased expression of PAD2 and citrullination of α-actin, which was triggered by TNF-α. This provides molecular and physiological evidence for an acquired cardiomyopathy and a potential mechanism for RA-associated heart failure.

查看译文

关键词

Ca2+ sensitivity,Citrullination,Heart Failure,PAD,Rheumatoid Arthritis

AI 理解论文

溯源树

样例

生成溯源树，研究论文发展脉络

Chat Paper

正在生成论文摘要