Chemotherapy dosing in older adults with cancer: One size does NOT fit all

Cancer is a disease of aging with nearly 60% of all cancer diagnoses and 70% of all cancer deaths occurring among older adults over the age of 65 years [1]. Older adults with cancer continue to be underrepresented in cancer clinical trials resulting in significant knowledge gaps regarding the management of older adults with cancer, including how to adapt and personalize conventional treatment strategies for older patients [2]. Severe and potentially life-threatening chemotherapy toxicities remain common in older adults with advanced cancer, as approximately over half of older patients experience grade 3–5 chemotherapy toxicities [3,4].