Topography of immune cell infiltration in different stages of coronary atherosclerosis revealed by multiplex immunohistochemistry.

Kimberley R.G. Cortenbach,Daniel Morales Cano,Jelena Meek,Mark A.J. Gorris,Alexander H.J. Staal,Mangala Srinivas,I. Jolanda M. de Vries,Jacob Fog Bentzon,Roland R.J. van Kimmenade

International journal of cardiology. Heart & vasculature（2023）

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摘要

The type of immune response does not differ substantially between different stages of plaque development and may provide context for mechanistic research into immune cell function in atherosclerosis. We provide the first comprehensive map of immune cell subtypes across plaque types in coronary arteries demonstrating the potential of mIHC for vascular research.

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Atherosclerosis,CAD, coronary artery disease,Coronary artery disease,EIT, eccentric intimal thickening,Inflammation,LAD, left anterior descending artery,MMP, matrix metalloproteinase,Multiplex immunohistochemistry,PIT, pathological intimal thickening,ROI, region of interest,SMC, smooth muscle cell,cDC2, conventional dendritic cell type 2,mIHC, multiplex immunohistochemistry

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