Characterization of outcomes of amino acid modifications using a combinatorial approach to reveal physical and structural perturbations: A case study using trastuzumab biosimilar

Ritu Kamble,Amita Puranik,Aditya Narvekar,Prajakta Dandekar,Ratnesh Jain

Journal of Chromatography B（2022）

引用 0|浏览1

暂无评分

摘要

•Correlation between amino acid modifications and biophysical characterization of trastuzumab.•Comparison of chemical modifications of amino acids due to forced degradation via oxidation, deamidation and glycation.•Analysis of site-specific amino acid modifications using mass spectrometry.•Biophysical characterization using DLS, SV-AUC, CD spectroscopy and DSC.

查看译文

关键词

Monoclonal antibodies,Forced degradation,Thermodynamic stability,Aggregation,Secondary structure

AI 理解论文

溯源树

样例

生成溯源树，研究论文发展脉络

Chat Paper

正在生成论文摘要