Adipose mTORC2 is essential for sensory innervation in white adipose tissue and whole-body energy homeostasis

Irina C. Frei,Diana Weissenberger,Danilo Ritz,Wolf Heusermann,Marco Colombi,Mitsugu Shimobayashi,Michael N. Hall

Molecular Metabolism（2022）

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摘要

•Whole-mount three-dimensional imaging revealed an extensive sensory neuronal network in white adipose tissue (WAT).•Adipose mTORC2 is required for arborization of sensory, but not sympathetic neurons in WAT.•Loss of sensory neurons in WAT coincides with systemic insulin resistance.•The neuronal protein GAP43 is a marker for sensory innervation in WAT.

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关键词

Adipose tissue,Whole-body energy homeostasis,mTORC2,Sensory nervous system,Diabetes,CGRP,Neuropathy

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