Comprehensive identification of immuno-related transcriptional signature for active pulmonary tuberculosis by integrated analysis of array and single cell RNA-seq

Yuzhong Xu,Yaoju Tan,Xianyi Zhang,Minggang Cheng,Jinxing Hu,Jianxiong Liu,Xinchun Chen,Jialou Zhu

Journal of Infection（2022）

引用 9|浏览7

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摘要

•Comprehensive illustration of immuno-related transcriptional signature for active pulmonary TB.•Immune transcriptional profiling could effectively differ TB with LTBI and HC.•First scRNA-seq-based description of ADM expression abundance in TB Myeloid cells.•ADM could be used as a novel biomarker for distinguishing patients with TB from LTBI and HC.

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关键词

Tuberculosis,Single-cell RNA sequencing,Transcriptional signature,Immuno-related hub gene,diagnostic biomarker,ADM

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