LipoxinA4 analog BML-111 protects podocytes cultured in high-glucose medium against oxidative injury via activating Nrf2 pathway

Hua Hao,Fangping Xie,Fen Xu,Qingyu Wang,Yun Wu,Dongxin Zhang

International Immunopharmacology（2022）

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摘要

•Nrf2 plays a key role in oxidative injury of podocytes cultured in high-glucose medium.•Lipoxin A4 analog BML-111 attenuates oxidative injury of podocytes cultured in high-glucose medium in vitro.•BML-111 attenuates diabetic kidney injury via Nrf2 pathway in vivo.

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关键词

Lipoxin A4,Diabetic kidney disease,Podocytes,Inflammation,Nrf2

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