Parkin Insufficiency Accentuates High-Fat Diet–Induced Cardiac Remodeling and Contractile Dysfunction Through VDAC1-Mediated Mitochondrial Ca2+ Overload

Ne N. Wu, Yaguang Bi,Amir Ajoolabady, Fei You,James Sowers, Qiurong Wang,Asli F. Ceylan, Yingmei Zhang,Jun Ren

JACC: Basic to Translational Science（2022）

引用 12|浏览9

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摘要

•Mitochondrial Ca2+ overload contributes to obesity-induced cardiac injury.•Parkin deletion aggravates obesity cardiomyopathy independent of systemic effects.•Parkin regulates VDAC1 degradation, but not other mitochondrial Ca2+ transporters.•Parkin expression or VDAC1 inhibition rescues cardiomyocyte contractile defect.

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关键词

Ca2+ overload,heart,high-fat diet,mitochondria,Parkin,VDAC1

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